20-Hydroperoxy cholesterol compounds for suppression of atherogenesis
AssigneeIowa State University Research Foundation, Inc.
InventorsCarl L. Tipton, Meiling Shih
Life of this patent
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Abstract
A method is provided for suppressing atherogenesis in which a cholesterol 20-hydroperoxide is administered, which is preferably one or both of the novel compounds: 20(R)-hydroperoxy-25-hydrocholesterol and 29(S)-hydroperoxy-25-hydrocholesterol.
Claims9
A method of suppressing atherogeneis in a human patient, comprising administering to the patient an amount of a cholesterol 20-hydroperoxide selected from the group consisting of 20(R)-hydroperoxy-25-hydroxycholesterol, 20(S)-hydroperoxy-25-hydroxycholesterol and mixtures thereof effective for reducing aortal deposit of cholesterol, said amount administered being in a dosage range from 0.5 to 25 milligrams of said cholesterol 20-hydroperoxide per kilogram of body weight per 24 hours.
A medication for prevention and/or treatment of atherogenesis in human patients, comprising an oral dose form of cholesterol 20-hyderoperoxide, said dose form being selected from tablets and capsules.
20(R)-hydroperoxy-25-hydroxycholesterol.
20(S)-hydroperoxy-25-hydroxycholesterol.
Dependencies are inferred from the claim text.