US 4,900,722 A · Methods and compositions for prophylactic and therapeutic treatment of infections

Abstract

A new class of soluble phosphorylated glucans is described as well as the process for making the same. According to one embodiment, the soluble phosphorylated glucan is derived from the yeast Saccharomyces cerevisiae. The soluble phosphorylated glucans are useful for prophylactic and therapeutic applications against neoplastic, bacteria, viral, fungal and parasitic diseases. The soluble phosphorylated glucans are used either alone or in combination with a known antimicrobial agent for prophylactic and therapeutic antimicrobial applications. Additionally, they may be administered as a non-toxic adjuvant, in combination with chemotherapy. The soluble phosphorylated glucans are also useful for stimulating macrophage cells, either in vivo or in vitro, to produce a cytotoxic/cyctostatic factor effective against cancer cells.

Claims16

Dependent claims

A method for treatment of an infection caused by a parasite in animals or humans, comprising:

administering to an animal or a human affected with said infection, a therapeutically effective amount of a soluble glucan which comprises a phosphorylated poly-[beta-(1-3)glucopyranose] chain which is characterized by:
(a) the capability of dissolving in water or an aqueous solution;
(b) being non-toxic, non-immunogenic and substantially non-pyrogenic;
and
(c) the capability of exerting a pronounced immunobiological response when administered in vivo to an animal or to a human.

2 more elements

Dependencies are inferred from the claim text.

Methods and compositions for prophylactic and therapeutic treatment of infections

Life of this patent

Methods and compositions for prophylactic and therapeutic treatment of infections

Life of this patent

Abstract

Claims16