Replacement of human plasma using sterile solution of human plasma proteins excluding blood coagulation factors

In the replacement of a patient's plasma with a substitute medium, the improvement which comprises employing as such substitute medium a sterile plasma-exchange medium containing the most essential human serum proteins, wherein said medium does not contain the blood coagulation factors at a concentration of about 75 g/l, and wherein said most essential human serum proteins comprise:

• ______________________________________ 10 to 80% normal blood content of antithrombin III, and 35 to 50 g/l of albumin, 6 to 12 g/l of IgG, 1.0 to 2.5 g/l of IgA, 0.5 to 2.5 g/l of IgM, 0.1 to 0.3 g/l of .alpha..sub.1 -antitrypsin, 0.1 to 0.3 g/l of .alpha..sub.2 -macroglobulin, and 0.05 to 0.15 g/l of complement C3. ______________________________________