Nitrosothiols as hypotensive agents
AssigneeThe Ohio State University
InventorsGary E. Means, Jeen W. Park
Life of this patent
Estimating the term…
Abstract
Systemic arterial pressure of an animal is decreased by administering directly to the animal an S-nitroso therapeutic compound, and particularly any of the S-nitrosoglutathione, D-(S-nitroso)-3-mercaptomethylpropionyl-L-proline, or S-nitrosothiol serum albumin in a dosage amount effective for a desired decrease and being an amount preferably between about 7 to 10 .mu.g/kg. animal weight/minute.
Claims3
A process for decreasing the systemic arterial pressure in an animal which comprises:
- administering directly to the animal of an aqueous composition containing S-nitrosoglutathione, which before placing in said aqueous composition had been in a therapeutically pure, relatively stable, solid form, which is characterizable by no change in its characteristic original absorbance at 545 nm upon storage in air for 30 days at 4.degree. C., and whose process of preparation had included reacting in aqueous solution of glutathione with a nitrite and a subsequent freezing with vacuum drying to provide said solid form, in a dosage amount effective for said decreasing and being the amount of at least about 7 .mu.g/kg. animal weight/minute or more.
S-nitrosoglutathione as a therapeutically pure relatively stable, solid form characterized by no change in its characteristic original absorbance at 545 nm upon storage in air for more than 30 days at 4.degree. and by a process of preparation which included reacting an aqueous solution of glutathione with a nitrite and a subsequent freezing with vacuum drying to provide said solid form.
Dependencies are inferred from the claim text.