CK-MM myocardial infarction immunoassay
AssigneeInternational Immunoassay Laboratories, Inc.
InventorsVipin D. Shah, Shing-Erh Yen, Gerald M. Anchin
Life of this patent
Estimating the term…
Abstract
Methods and reagents for early detection of myocardial infarction determine the level of CK-MM.sub.A and the level of the combined CK-MM.sub.A and CK-MM.sub.B in a serum sample. From these measurements, the time of the acute phase can be more accurately determined. Novel anti-(CK-MM.sub.A) antibodies, anti-(CK-MM.sub.B) antibodies, anti-(CK-MM.sub.(A+B)) antibodies, labeled and insolubilized derivatives of these antibodies, labeled CK-MM isoforms, and kits containing one or more of these reagents are also described.
Claims26
A method for determined the level of CK-MM.sub.A in a serum or plasma sample comprising interacting said sample with anti-(CK-MM.sub.A) antibody, and determining the level of CK-MM.sub.A bound with anti-(CK-MM.sub.A) antibody.
A method for determining the level of CK-MM.sub.B in a serum or plasma sample comprising interacting said sample with anti-CK-MM.sub.B) antibody, and determining the level of CK-MM.sub.B bound with anti-CK-MM.sub.B) antibody.
A method for determining the level of CK-MM.sub.(A+B) in a serum or plasma sample comprising interacting said sample with anti-(CK-MM.sub.(A+B) antibody, and determining the CK-MM.sub.(A+B) bound with anti-(CK-MM.sub.(A+B) antibody.
An anti-(CK-MM.sub.A) antibody preparation which does not bind significantly with CK-MB, CK-MM.sub.B or CK-MM.sub.C.
An anti-(CK-MM.sub.B) antibody preparation which does not bind significantly with CK-MB, CK-MM.sub.A or CK-MM.sub.C.
An anti-(CK-MM.sub.(A+B)) antibody preparation which binds with CK-MM.sub.A or CK-MM.sub.B, but does not bind significantly with CK-MB, or CK-MM.sub.C.
An assay kit containing an anti-(CK-MM.sub.A) antibody and an anti-(CK-MM.sub.(A+B)) antibody.
Dependencies are inferred from the claim text.