Streptococcal fc rc
AssigneeUniversity of Florida
InventorsMichael D. P. Boyle, Kathleen J. Reis, Elia M. Ayoub
Life of this patent
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Abstract
Proteinaceous, antigenic factor derived from a group C Streptococcus which is receptor for the Fc region of IgG, a method for its preparation and immunoassay and antigen detection methods employing the receptor.
Claims24
In an immunoassay method wherein a bacterial Fc receptor is reacted with a mammalian IgG to bind to a site within the Fc region thereof, the improvement wherein said bacterial Fc receptor is a proteinaceous, antigenic factor derived from a group C streptococcus which is a receptor for the Fc region of IgG and which exhibits four major diffuse protein bands on polyacrylamide gel electrophoresis having apparent molecular weights of 48,000 (band I), 64,000 (band II), 90,000 (band III) and 110,000 (band IV) daltons, respectively.
In an immunoassay method wherein a bacterial Fc receptor is reacted with a mmalian IGg to bind to a site within the Fc region thereof, the improvement wherein said Fc receptor is a homogenous proteinaceous, antigenic factor derived from a group C streptococcus which is a receptor for the Fc region of IGg and which exhibits one major diffuse protein band on polyacrylamide gel electrophoresis and has an apparent molecular weight of 30,000 daltons.
Purified proteinaceous, antigenic factor derived from a group C streptococcus which is a receptor for the Fc region of IgG and which exhibits four major diffuse protein bands on polyacrylamide gel electrophoresis having apparent molecular weights of 48,000 (band I), 64,000 (band II), 90,000 (band III) and 110,000 (band IV) daltons, respectively.
A homogeneous, proteinaceous, antigenic factor derived from a group C streptococcus which is a receptor for the Fc region of IgG and which exhibits one major diffuse protein band on polyacrylamide gel electrophoresis and has an apparent molecular weight of 30,000 daltons.
Dependencies are inferred from the claim text.