Stabilized enteric coated aspirin granules and process of preparation
AssigneeBriston-Myers Company
InventorMahesh K. Patell
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Abstract
A stabilized enteric coated aspirin granule product prepared by commingling the enteric coated aspirin granules with glutamic acid hydrochloride.
Claims11
A unit dosage form consisting essentially of enteric coated aspirin granules commingled with an amount of glutamic acid hydrochloride powder sufficient to reduce hydrolysis of the aspirin in the enteric coated granules, wherein the glutamic acid hydrochloride is present in an amount of from about 1% to about 5% by weight, based on the total weight of the enteric coated aspirin granules, wherein the aspirin granules are enteric coated with an enteric material selected from the group consisting of polyvinyl acetate phthalate, ethyl cellulose, cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, copolymers of methacrylic acid and acrylic acid esters, and mixtures thereof.
Dependencies are inferred from the claim text.