US 4,900,558 A · Sustained release ibuprofen formulation including a core of ibuprofen and a microcrystalline cellulose and a covering of acrylic polymer and hydroxylated cellulose derivative

Abstract

The present invention provides a sustained release .alpha.methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) formulation comprising sufficient granules to provide a predetermined dose or number of doses of Ibuprofen, each granule having a diameter between 0.5 and 2.0 mm and comprising: (a) a core containing 100 parts of Ibuprofen and from 10 to 70 parts of a microcrystalline cellulose; and (b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and 20 to 70 parts of a water-soluble hydroxylated cellulose derivative, the weight of the coating being from 5 to 20% of the weight of the core.

Claims10

Dependent claims

A sustained release .alpha.-methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) formulation comprising sufficient granules to provide a dose or number of doses of Ibuprofen, each granule having a diameter between 0.5 and 2.0 mm and comprising:

(a) a core containing 100 parts of Ibuprofen and from 10 to 70 parts of a microcrystalline cellulose;
and
(b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and 20 to 70 parts of a water-soluble hydroxylated cellulose derivative, the weight of the coating being from 5 to 20% of the weight of the core.

Dependencies are inferred from the claim text.

Facts

Application

07/079,206Filed 30 Jul 1987

Priority

GB 86188111 Aug 1986

Granted

13 Feb 1990

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid
A61K 9/1652
Organic macromolecular compounds: polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
A61K 9/5026
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates
A61K 9/5047
Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose: cellulose ethers containing no…

Sustained release ibuprofen formulation including a core of ibuprofen and a microcrystalline cellulose and a covering of acrylic polymer and hydroxylated cellulose derivative

Life of this patent

Sustained release ibuprofen formulation including a core of ibuprofen and a microcrystalline cellulose and a covering of acrylic polymer and hydroxylated cellulose derivative

Life of this patent

Abstract

Claims10