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US 4,900,557 AGranted
Pellet formulation
AssigneeTroponwerke GmbH & Co. KG
InventorsHans-Dieter Dell, Reinhold Kraus, Detlef Schierstedt
Life of this patent
Estimating the term…
Abstract
The invention relates to pellet formulations which (a) contain at least one active compound, one binder and one weighting agent, (b) are coated with a lacquer which is resistant to gastric juice or have been granulated in the presence of a lacquer which is resistant to gastric juice, it being possible, if appropriate, for the granules to be coated with a lacquer which is resistant to gastric juice, (c) have an apparent density of 1.4 to 2.4 and (d) have a diameter of 0.2 to 1.8 mm.
Claims7
A sustained release formulation comprising pellets
- (a) containing acemetacin and at least, one binder, one weighting agent and one disintegrant,
- (b) coated with a lacquer which is resistant to gastric juice or granulated in the presence of a lacquer which is resistant to gastric juice, and
- (c) having an apparent density of 1.4 to 2.4 and having a diameter of 0.2 to 1.8 mm and an initial dose of acemetacin which comprises 10 to 60% by weight, based on the total weight of the acemetacin of the pellet in free form.
Dependencies are inferred from the claim text.