Lipisomes containing gas for ultrasound detection
AssigneeTrustees of the University of Massachusetts
InventorsPatrick J. Ryan, Michael A. Davis, Donald L. Melchior
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Abstract
Phospholipid liposomes are provided having a lipid bilayer surrounding a confined composition which includes a gas or a gas precursor. The liposomes can be administered to a patient and can be detected in vivo by ultrasound techniques which permit organ imaging.
Claims3
Phospholipid liposomes, for use as an ultrasound contrast medium, comprising an outer phospholipid layer and, confined by said layer a gas precursor selected from the group consisting of aqueous sodium bicarbonate and aqueous aminomalonate in an amount effective to form a gas under physiological pH conditions.
Dependencies are inferred from the claim text.