Novel retinoids

Abstract

The novel compounds of the formula Ret-OA I wherein Ret is the acyl residue of a retinoid carboxylic acid, A is a residue (--CHR)--CH.sub.2 O).sub.n R.sup.1, (--CH.sub.2).sub.m SR.sup.1, (--CH.sub.2).sub.m XR.sup.2, (--CH.sub.2).sub.m --Het, --N(R.sup.2).sub.2, --C(R.sup.4).sub.2 OC(O)R.sup.3, --CH.sub.2 --CH(OR.sup.2)CH.sub.2 OR.sup.2 or --CH(CH.sub.2 OR.sup.2).sub.2 ; R is hydrogen or methyl, R.sup.1 is hydrogen, C.sub.1-6 -alkyl or C.sub.1-6 -alkanoyl, R.sup.2 is C.sub.1-6 -alkyl, R.sup.3 is C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, di-C.sub.1-6 -alkylamino, phenyl, substituted phenyl, styryl or styryl or 2-benzoyl-phenoxy-C.sub.1-6 -alkyl substituted in the phenyl residue; R.sup.4 is hydrogen, C.sub.1-6 -alkyl or phenyl; X is >SO or >SO.sub.2, Het is the residue of a N-heterocyclic ring, n is a whole number of 3-40 and m is a whole number of 1-4, with the proviso that R.sup.1 is C.sub.1-6 -alkyl or C.sub.1-6 -alkanoyl when A is a --CH.sub.2 SR.sup.1, can be used as medicaments, especially for the topical treatment of dermatological disorders. The novel compounds are obtainable e.g. by esterifying a retinoid carboxylic acid Ret-OH with an alcohol HA and, if desired, subsequently transforming reactive groups in the molecule.

Dependencies are inferred from the claim text.