A porous membrane for blood components and method for manufacturing thereof
AssigneeTerumo Kabushiki Kaisha
InventorsYukio Seita, Makoto Onishi
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Abstract
A porous membrane for use in the separation of blood components, made of a polyolefin, having a wall thickness in the range of 10 to 500 .mu.m, and possessing through holes having an average diameter of 0.01 to 5 .mu.m at a porosity in the range of 10 to 85%, which porous membrane is characterized by exhibiting a shrinkage of not more than 6.0% in a heat treatment carried out at 121.degree. C. for 120 minutes. A method for the manufacture of the porous membrane is also disclosed.
Claims10
A method for manufacturing a porous membrane for use in the separation of blood components comprising:
- mixing a molten polyolefin, an organic filler uniformly dispersible in said polyolefin while maintaining said polyolefin in a molten state and easily soluble in an extractant, and a crystal seed-forming agent which is an organic heat resistant substance having a melting point of not less than 150.degree. C. and a gel point exceeding the crystallization initiating point of said polyolefin,
- causing the resultant mixture in the molten state to be discharged through a die whereby a molten membrane is obtained,
- solidifying the thus discharged molten membrane by cooling,
- separating said organic filler from the solidified membrane by contacting the solidified membrane with an extractant incapable of dissolving said polyolefin, said extractant stripping said organic filler from said membrane by extraction whereby the polyolefin membrane is obtained, and
- fixing the thus produced polyolefin membrane in a prescribed length and subjecting said fixed polyolefin membrane to a heat treatment at a temperature of 20.degree. C. to 50.degree. C. lower than the melting point of said polyolefin.
A flat permeable membrane having a thickness of 10 to 500.mu.m and having in one surface thereof as a filtering surface a compact layer formed from intimately bound fine polyolefin particles possessed of fine pores and in the interior and other surface thereof a layer formed of an aggregate of fine discreet polyolefin particles of an average diameter on the range of 0.01 to 5.mu.m so adjoined so as form fine labyrinthically continuing through pores and which, therefor, establish communication between the surfaces of said membrane, obtained by:
- mixing a polyolefin, an organic filler uniformly disbursed and said polyolefin in the molten state thereof, and a crystal seed-forming agent, discharging the resultant mixture in the molten state thereof through a die;
- contacting one surface of the thus discharged molten membrane with a cooling roll thereby cooling and solidifying said membrane;
- placing the cooled solidified flat membrane into contact with an extractant incapable of dissolving said polyolefin thereby extracting and removing said organic filler from the said membrane;
- and
- affixing said membrane into a prescribed length and maintaining said membrane in said condition while subjecting the thus formed membrane to a heat treatment at a temperature of 20.degree. C. to 50.degree. C. lower than the melting point of said polyolefin.
Dependencies are inferred from the claim text.