Process for producing an anti-thrombogenic material by graft polymerization
AssigneesJapan Atomic Energy Research Inst., Sumitomo Bakelite Co., Ltd.
InventorsTakanobu Sugo, Jiro Okamoto, Seiryo Tasaki, Tadayuki Onishi
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Abstract
A process for producing a medical material having high anti-thrombogenicity that is suitable for use in catheters and other medical devices in contact with blood flowing in circulatory organs and other tissues is disclosed. According to this process, an acrylamide or methacrylamide derivative having a tertiary amino group, or an unsaturated monomer having a hydrophihlic group and the ability to promote copolymerization, or a mixture thereof is graft polymerized onto a polyurethane elastomeric or polyolefinic high-molecular weight substrate with an ionizing radiation.
Claims3
A process for producing an anti-thrombogenic material in which
- an acrylamide or methacrylamide selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethyl aminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N-diethylaminopropylmethacrlamide, and
- a copolymerization promotor of at least one unsaturated monomer selected from the group consisting of an acrylate or methacrylate having an oligooxyethylene group whose degree of polymerization is 2-10, an acrylate or methacrylate having a hydrocarbon group with no more than 3 carbon atoms into which an alcoholic or glycolic hydroxyl group has been introduced, and acrylamide and N-vinylpyrrolidone
- are graft polymerized with an ionizing radiation onto a high-molecular weight substrate comprising a polyurethane elastomeric polymer or a polyolefinic polymer.
A process for producing an anti-thrombogenic material which comprises generating active sites on a polyurethane elastomeric or polyolefinic high-molecular weight substrate by treatment with an ionizing radiation, and immersing the treated substrate in a solution of an acrylamide or methacrylamide having a tertiary amino group selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethylaminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N-diethylaminopropylmethacrylamide, so as to effect graft polymerization.
A process for producing an anti-thrombogenic material which comprises immersing a polyurethane elastomeric high-molecular weight substrate in a mixed solution of
- an acrylamide or methacrylamide selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethyl aminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N diethylaminopropylmethacrylamide, and
- a copolymerization promotor of at least one unsaturated monomer selected from the group consisting of an acrylate or methacrylate having an oligooxyethylene group whose degree of polymerization is 2-10, an acrylate or methacrylate having a hydrocarbon group with no more than 3 carbon atoms into which an alcoholic or glycolic hydroxyl group has been introduced, an acrylamide and N-vinylpyrrolidone, and
- applying an ionizing radiation to effect co-graft polymerization.
Dependencies are inferred from the claim text.