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US 4,895,868 AGranted
Thiochroman esters of phenols and terephthallates having retinoid-like activity
AssigneeAllergan, Inc.
InventorRoshantha A. S. Chandraratna
Life of this patent
Estimating the term…
Abstract
Compounds of formula I ##STR1## in which: the R groups are independently hydrogen or lower alkyl; one of A and B is O or S and the other is --C(O)--, A being attached to the thiochroman ring at the 6 or 7-position; n is 0-5; and Z is H, an acid or acid derivative, an alcohol or alcohol derivative, acetal or acetal derivative or ketone or ketone derivative, or a pharmaceutically acceptable salt, have retinoid-like activity.
Claims15
A compound of the formula:
- ##STR7## in which:
- the R groups are independently hydrogen or lower alkyl;
- one of A and B is O or S and the other is --C(O)--, A being attached to the thiochroman ring at the 6 or 7-position;
- n is 0-5;
- and
- Z is H, or Z is --COD where D is --OH, or --OM wherein M is a pharmaceutically acceptable cation, or D is --OR.sub.1 is a lower alkyl group, or D is --N(R.sub.2).sub.2 where R.sub.2 is hydrogen or a lower alkyl group, or Z is --OE where E is hydrogen or a C.sub.1-20 aliphatic, cycloaliphatic, or aliphatic-phenyl ether-forming group or a C.sub.1-10 aliphatic or cycloaliphatic carboxylic acid ester forming group or a phenyl or lower alkyl phenyl carboxylic acid ester forming group, or Z is --CHO or a lower alkyl acetal thereof, or Z is --COR.sub.3 where R.sub.3 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4 and the sum of n and m does not exceed 4 or a lower alkyl ketal derivative thereof.
3 more elements
Dependencies are inferred from the claim text.