Antibiotic TAN-950A, its production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsTakashi Iwasa, Shigetoshi Tsubotani, Setsuo Harada
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Abstract
As the novel antibiotic TAN-950A having the structural formula ##STR1## and salt thereof of the present invention show antimicrobial action against fungi, they can be used in the therapeutics of fungal infections, in human and other animals etc. by oral, parenteral or external administration.
Claims2
Antibiotic TAN-950A or a salt thereof, whereof the monosodium salt has the following physico-chemical properties:
- (1) Appearance:
- White solid
- (2) Molecular formula:
- C.sub.6 H.sub.7 N.sub.2 O.sub.4 Na
- (3) Ultraviolet (UV) absorption spectrum:
- in water .lambda.max 253.+-.3 nm (E.sub.1 cm.sup.1% =380.+-.50)
- (4) Infrared (IR) absorption spectrum:
- in KBr Main absorption wavenumbers (cm.sup.-1) 3430, 1640, 1500, 1410, 1350, 1180, 1070, 930, 870, 810, 750, 610, 530
- (5) .sup.1 H-nuclear magnetic resonance (NMR) spectrum:
- 400 MHz, in deuterium oxide The following signals are observed (.delta..sub.ppm J.sub.(Hz)) 2.70 (1H, dd, J=7.3, 15.6), 2.80 (1H, dd, J=4.4, 15.6), 3.86 (1H, dd, J=4.4, 7.3), 7.98 (1H, s)
- (6) .sup.13 C-NMR spectrum:
- 100 MHz, in deuterium oxide The following signals are observed (.delta..sub.ppm) 180.6 (s), 177.1 (s), 158.5 (s), 82.9 (s), 58.5 (d), 26.5 (t) and having this structural formula:
- ##STR3##
An antifungal composition useful for treating fungal infections, which contains an effective amount of antibiotic TAN-950having the structural formula ##STR4## or a non-toxic salt thereof, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.