Novel benzyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents
AssigneeAmerican Home Products Corporation
InventorsThomas R. Alessi, Terence M. Dolak
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Abstract
This invention relates to novel benzyl-3H-1,2,3,5-oxathiadiazole 2-oxides, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
Claims17
The compounds of structural formula (I) ##STR10## wherein R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, lower alkyl or alkoxy containing 1 to 6 carbon atoms, halogen, trifluoromethyl, nitro, vinyl, ethynyl, alkylthio wherein alkyl contains 1 to 4 carbon atoms, nitrile, phenyl, phenyl- or halogen substituted phenylalkoxy wherein alkoxy contains 1 to 4 carbon atoms or the pharmaceutically acceptable salts thereof.
A method of treating non-insulin dependent diabetes mellitus in humans by administering an effective amount of the compound of formula (I).
A pharmaceutical composition useful for treating non-insulin dependent diabetes mellitus in humans comprising an effective amount of a compound of formula (I) and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.