Method and apparatus for administering dehydrated liposomes by inhalation
AssigneeLiposome Technology, Inc.
InventorsRamachandran Radhakrishnan, Paul J. Mihalko, Robert M. Abra
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Abstract
A system and method for administering a drug, at a selected dose, via the respiratory tract. Spray-dried liposome particles containing the selected dose of the entrapped drug are released into the air in aerosolized form, either by entrainment in an air or propellant stream, or by release from a pressurized can containing a suspension of the liposomes in a fluorchlorocarbon solvent.
Claims18
Apparatus for administering a water-soluble drug, at a selected dose, via the respiratory tract comprising
- dehydrated liposome particles formed by the steps of (a) producing a liposome suspension having at least about 50% liposome-encapsulated drug, and (b) dehydrating the suspension, and
- a device for producing an airborne suspension of the liposome particles containing such selected dose of the drug.
A method for administering a water-soluble drug, at a selected dose, to the respiratory tract comprising
- providing dehydrated liposome particles formed by the steps of (a) producing a liposome suspension having at least about 50% liposome-encapsulated drug, and (b) dehydrating the suspension, and
- producing an airborne suspension of the liposome particles containing the selected dose of the drug.
Dependencies are inferred from the claim text.