Method for preparing vitamin D compounds
AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsSadafumi Omura, Joji Sasaki, Akiko Mikami, Kazutoshi Mizoue
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Abstract
A method for introducing hydroxyl groups into vitamin D compounds at 1.alpha.- and/or 25-positions by use of a solution containing the mycelium of Actinomycetales being capable of hydroxylating vitamin D compound or the enzyme produced from the mycelium, is disclosed.
Claims10
A method for preparing a 1.alpha.- or 25-hydroxyvitamin D compound which comprises adding a vitamin D compound having a hydrogen atom at the 1.alpha.- or 25-position to a reaction mixture containing a mycelium of Actinomycetales being capable of hydroxylating the vitamin D compound or to a reaction mixture containing the enzyme produced from said mycelium and converting the hydrogen atom into a hydroxyl group.
A method for preparing a 25-hydroxyvitamin D compound or 1.alpha., 25-dihydroxyvitamin D compound which comprises adding a vitamin D compound having hydrogen atoms at the 1.alpha.- and 25-positions to a reaction mixture containing a mycelium of Actinomycetales being capable of hydroxylating the vitamin D compound or to a reaction mixture containing enzyme produced from said mycelium and converting the hydrogen atoms into hydroxyl groups.
Dependencies are inferred from the claim text.