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US 4,892,733 AGranted
Biodegradable synthesis polypeptide and its therapeutic use
AssigneeImperial Chemical Industries PLC
InventorsDaniel Bichon, Bernard Lamy, William Borloz
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Abstract
Derivatives of polyaspartic and/or polyglutamic acids whose side chains bear COOH groups capable to cyclize into anhydride. These polyacids and anhydrides can be used to manufacture medicines.
Claims20
Hydrosoluble, biodegradable, carboxylated polypeptide derived from polyaspartic and/or polyglutamic acids, of formula ##STR21## or its copolymers with other aminoacids, of formula ##STR22## in which:
- R and R' are side chains of aminoacids, and R' is the same or different than R;
- m is an integer from 0 to 5;
- p is 0, 1 or 2;
- n is 1 or 2;
- x is selected so that the molecular weight of the polypeptide is at least 5000 Dalton;
- and
- x=y+z with the ratio of y/z being in the range of about 1 to about 30.03.
4 more elements
The method of use of polymer I and copolymers II as antiviral and antitumor drugs.
Dependencies are inferred from the claim text.