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US 4,891,225 AGranted
Bioerodible polyanhydrides for controlled drug delivery
AssigneeMassachusetts Institute of Technology
InventorsRobert S. Langer, Howard Rosen
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AssigneeMassachusetts Institute of Technology
InventorsRobert S. Langer, Howard Rosen
Estimating the term…
A novel hydrophobic polymeric matrix is provided which is suitable for use after implantation in vivo in a subject for the controlled release and delivery of biologically active substances such as drugs, antibiotics, steroids and the like. Alternatively, the matrix can be used outside the body for release of fragrances, pesticides and the like. The implantable matrix comprises a polymeric polyanhydride formulation whose internal anhydride linkages are hydrolytic in nature in varying degrees in accordance with the chemical composition of the backbone, pH and temperature of the environment. As the individual anhydride linkages become hydrolyzed, the matrix erodes predominantly by surface erosion into non-toxic biocompatible degradation products with concomitant release of the biologically active substance.
A zero-order release rate polymeric device comprising a hydrophobic polyanhydride polymeric composition degrading by surface erosion, said composition having the formula ##STR2## wherein R and R' are selected from the group consisting of compositions having a molecular weight not substantially greater than 500 daltons and wherein m and n are at least 1, and at least one biologically active substance;
A zero-order release rate polymeric device comprising a hydrophobic polyanhydride polymeric composition degrading by surface erosion, said composition having the formula ##STR3## wherein R and R' are selected from the group consisting of compositions having a molecular weight not substantially greater than 500 daltons and wherein m and n are at least 10, and at least one biologically active substance;
Dependencies are inferred from the claim text.