Inhibitors of slow reacting substance of anaphylaxis

A compound having the structural formula II or a pharmaceutically acceptable salt thereof, ##STR9## wherein T is a straight or branched chain alkyl having from 7-15 carbon atoms which may optionally contain from 1-3 non-cumulative double or triple bonds;

• U is --C.tbd.C--;
• V is a straight or branched chain alkylene having from 1 to 4 carbon atoms or is a direct bond;
• W represents O or S(O).sub.m wherein m is 0, 1 or 2;
• X is a straight or branched chain alkylene having from 2 to 12 carbon atoms which may optionally contain from 1 to 3 non-cumulative double or triple bonds and which may be optionally substituted with a group --NHR.sup.a {wherein R.sup.a is hydrogen, alkyl having from 1 to 6 carbon atoms, COCF.sub.3, CO(CH.sub.2).sub.2 CH(NH.sub.2)CO.sub.2 H, or SO.sub.2 R.sup.b and wherein R.sup.b is alkyl having from 1 to 6 carbon atoms or CF.sub.3 };
• Y represents straight or branched chain alkylene having from 1 to 12 carbon atoms which is substituted with the group OR.sup.c {wherein R.sup.c is hydrogen, carboxylic acyl having from 1 to 6 carbon atoms, tetrahydropyran-2-yl, or COCH.sub.2 CH.sub.2 CO.sub.2 H} and may optionally contain from 1 to 3 non-cumulative double or triple bonds;
• and
• R.sup.2 and R.sup.3 may be the same or different and are independently selected from CH.sub.2 OR.sup.c {wherein R.sup.c is hydrogen, carboxylic acyl having from 1 to 6 carbon atoms, tetrahydropyran-2-yl or COCH.sub.2 CH.sub.2 CO.sub.2 H}, CHO, COR.sup.d {wherein R.sup.d is hydroxy, alkoxy having from 1 to 6 carbon atoms, OCH.sub.2 OC(O)C(CH.sub.3).sub.3, or NHR.sup.e and wherein R.sup.e is hydrogen, alkyl having from 1 to 6 carbon atoms or CH.sub.2 CO.sub.2 H} or SO.sub.3 H, with the proviso that at least one of R.sup.2 and R.sup.3 is carboxyl.