Carbapenem compound in crystalline form, and its production and use
AssigneeSumitomo Pharmaceuticals Company, Limited
InventorsMakoto Sunagawa, Yutaka Isobe, Yutaka Takeuchi, Haruki Matsumura, Yukio Ozaki, Tetsuo Noguchi
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Abstract
(4R,5S,6S 8R,2'S,4'S)-3-[4-(2-Dimethylaminocarbonyl)pyrrolidinylthio]-4-methyl-6-(1- hydroxyethyl)-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid of the formula: ##STR1## in a crystalline form, which is useful as an antibiotic agent.
Claims4
Crystalline (4R, 5S, 6S, 8R, 2'S, 4'S)-3-[4-(2-Dimethylaminocarbonyl)pyrrolidinylthio]-4-methyl-6-(1-hydroxy ethyl)-1-azabicyclo [3.2.0]hept-2-en-7-one-2-carboxylic acid trihydrate of the formula:
- ##STR17##
A pharmaceutical composition for being dissolved in a physiologically acceptable aqueous medium and injected into a human body, which comprises as an active ingredient crystalline (4R, 5S, 6S, 8R, 2'S, 4'S)-3-[4-2-dimethylaminocarbonyl)pyrrolidinylthio]-4-methyl-6-(1-hydroxye thyl)-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid trihydrate of the formula:
- ##STR18## and a non-toxic carbonate.
Dependencies are inferred from the claim text.