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US 4,888,335 AGranted
3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents
AssigneeMcNeilab, Inc.
InventorsRichard J. Mohrbacher, Philip P. Grous
Life of this patent
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Abstract
Propylamines of the formula (I): ##STR1## and isomers thereof, particularly those enantiomers and racemates relative to the chiral carbon indicated by an asterisk (*). The propylamines can be used for the treatment of hypertension or angina in humans. A is pyrrolidine, piperidine or morpholine, Z is alkylene, alkenylene, oxygen or a sulfur atom and W is an oxygen or a sulfur atom.
Claims20
A propylamine of the following formula (I):
- ##STR5## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen, lower alkyl or lower alkenyl groups or --CR.sup.1 R.sup.2 R.sup.3 represents a lower alkenyl group, or R.sup.1 is a hydrogen, lower alkyl or lower alkenyl group and R.sup.2 and R.sup.3 are joined to form a cycloalkyl group of 3 to 8 carbons or R.sup.1, R.sup.2 and R.sup.3 are joined to form a polycyclicalkyl group of 7 to 12 carbons;
- W is an oxygen or a sulfur atom;
- X is independently selected from the group consisting of halo, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, or, when n is 2 on adjacent carbons, methylenedioxy;
- Y is independently selected from the group consisting of halo, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, or, when m is 2 on adjacent carbons, methylenedioxy;
- Z is --(CH.sub.2).sub.p --, --CR.sup.4 =CR.sup.5 -or --CHR.sup.4 --CHR.sup.5 --
- R.sup.4 is hydrogen or lower alkyl;
- R.sup.5 is hydrogen or lower alkyl;
- A represents the atoms necessary to form a pyrrolidine, piperidine or morpholine ring;
- k is 0 or 1;
- m is 0, 1, 2 or 3;;
- n is 0, 1, 2 or 3;
- p is 1, 2 or 3;
- q is 0 or 1,
- and the pharmaceutically acceptable acid addition salts thereof.
11 more elements
Dependencies are inferred from the claim text.