Novel pyrimidopyrimidine derivative, process for producing it and pharmaceutical composition
AssigneeNippon Zoki Pharmaceutical Co., Ltd.
InventorsNorihiko Kitamura, Akimoto Ohnishi
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Abstract
Pyrimidopyrimidine derivatives having the general formula ##STR1## wherein R.sub.1 is an alkyl group; R.sub.2 is an alkyl or phenyl group; R.sub.3 is a hydrogen atom, an alkyl or lower alkylamino group; and R.sub.4 is a hydrogen atom, an alkyl, halogenated lower alkyl, phenyl, amino or lower alkylamino group; and pharmaceutically acceptable salts thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.
Claims4
A pyrimidopyrimidine compound of the formula (I):
- ##STR18## whereinR.sub.2 is an alkyl group having 1 to 3 carbon atoms, and
- R.sub.4 is an alkyl group having 1 to 3 carbon atoms;
- a halogenated alkyl group having 1 to 3 carbon atoms, an amino group or an amino group substituted by an alkyl group having 1 to 3 carbon atoms,
- or a pharmaceutically acceptable salt thereof.
A method for treating mammals suffering from bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis which comprises administering thereto a pyrimidopyrimidine compound having the formula (I):
- ##STR19## wherein is a lower alkyl group. R.sub.4 is a hydrogen atom, a lower alkyl group, a halogenated lower alkyl group, a phenyl group, an amino group or an amino group substituted by a lower alkyl group;
- or a pharmaceutically acceptable salt thereof.
An anti-allergic compositions which comprises a pharmaceutically acceptable carrier and an effective anti-allergic pyrimidopyrimidine compound having the formula (I):
- ##STR20## wherein R.sub.2 is an alkyl group having 1 to 3 carbon atoms, and
- R.sub.4 is an alkyl group having 1 to 3 carbon atoms, a halogenated alkyl group having 1 to 3 carbon atoms, an amino group or an amino group substituted by an alkyl group having 1 to 3 carbon atoms,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.