New types of organometallic reagents and catalysts for asymmetric synthesis
AssigneeIowa State University Research Foundation, Inc.
InventorJohn G. Verkade
Life of this patent
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Abstract
New chiral catalysts for asymmetric synthesis reactions. The catalysts induce chirality in desired fashion in product molecules. The catalysts are rigid quadruped or triped ligands which provide a rigid asymmetric enantio-face at the active catalyst cite, thus inducing preparation of enantiomer molecules.
Claims9
Chiral catalysts having quadriped ligands for induction of chirality in reaction product molecules, said catalysts having the formula:
- ##STR6## wherein M is a transition metal selected from the group consisting of palladium, rhodium, platinum, nickel, titanium, zirconium and hafnium, E, E', E", and E'" corners are selected from the group consisting of organo electron donor moieties of phosphorus, nitrogen, arsenic, oxygen, sulfur, wherein y is from about 1 to about 3, x is from 0 to about 4, R and R' are selected from the group consisting of hydrogen, C.sub.1 to C.sub.10 alkyl, phenyl, and ring systems wherein R and R' are (CH.sub.2).sub.z and z is from 1 to 4.
Chiral catalysts having triped ligands for induction of asymmetry into reacton product molecules yielded from reactions catalyzed by said catalysts, said catalysts having the formula:
- ##STR7## wherein M is a transition metal selected from the group consisting of palladium, rhodium, platinum, nickel, titanium, zirconium and hafnium, E, E', and E" are selected from the group consisting of electron donor moieties of phosphorus, nitrogen, arsenic, oxygen, sulfur, and R and R' are selected from the group consisting of hydrogen,, C.sub.1 to C.sub.10 alkyl, phenyl and ring systems wherein R and R' are (CH.sub.2).sub.z and z is from 1 to 4, and R"' is a hydrogen, aryl or C.sub.1 to C.sub.10 alkyl.
Dependencies are inferred from the claim text.