1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
AssigneeE. R. Squibb & Sons, Inc.
InventorsMichael F. Tweedle, Glen T. Gaughan, James T. Hagan
Life of this patent
Estimating the term…
Abstract
Metal-chelating liquids having the formula ##STR1## wherein Y is oxygen or ##STR2## R.sub.1 is hydrogen, alkyl, arylalkyl aryl, alkoxy, hydroxyalkyl ##STR3## wherein G is ##STR4##
Claims144
A compound having the formula ##STR26## or a pharmaceutically acceptable salt thereof, wherein Y is oxygen or ##STR27## R.sub.1 is hydrogen, alkyl having from one to five carbon atoms, arylalkyl wherein the aryl portion is phenyl or substituted phenyl or phenyl substituted phenyl, alkoxy having from one to five carbon atoms, hydroxyalkyl wherein the alkyl portion has from one to five carbon atoms and having one or more hydroxy groups ##STR28## wherein G is ##STR29## wherein R.sub.4 is alkyl or hydroxyalkyl, ##STR30## wherein n and m are zero or an integer from one to five, R.sub.2 is hydrogen or alkyl, R.sub.3 is hydrogen, hydroxyalkyl having from one to five carbon atoms and having and one or more hydroxy groups, alkoxy having from one to five carbon atoms, phenyl or substituted phenyl or phenylalkyl or substituted phenylalkyl and X is chloro, bromo or iodo and wherein R.sub.1 is --(CH.sub.2).sub.n G, n is one and R.sub.2 is hydrogen then G is not CO.sub.2 H, wherein the term substituted phenyl refers to phenyl groups substituted with one, two, or three halogen, hydroxyl, alkyl, alkoxy carbamoyl or carboxyl groups.
A complex, or a pharmaceutically acceptable salt of a complex, of a metal atom and a metal-chelating ligand having the formula ##STR37## wherein Y is oxygen or ##STR38## R.sub.1 is hydrogen, alkyl having from one to five carbon atoms, arylalkyl wherein the aryl portion is phenyl or substituted phenyl, phenyl or substituted phenyl, alkoxy having from one to five carbon atoms, hydroxyalkyl wherein the alkyl portion has from one to five carbon atoms and having one or more hydroxy groups ##STR39## wherein G is ##STR40## wherein R.sub.4 is alkyl or hydroxyalkyl, ##STR41## wherein n and m are zero or an integer from one to five, R.sub.2 is hydrogen or alkyl, R.sub.3 is hydrogen, hydroxyalkyl having from one to five carbon atoms and having one or more hydroxy groups, alkoxy having from one to five carbon atoms, phenyl or substituted phenyl or phenylalkyl or substituted phenylalkyl and X is chloro, bromo or iodo and wherein R.sub.1 is --(CH.sub.2).sub.n G, n is one and R.sub.2 is hydrogen then G is not CO.sub.2 H, wherein the term substituted phenyl refers to phenyl groups substituted with one, two or three halogen, hydroxy, alkyl, alkoxy carbamoyl or carboxyl groups.
A compound having the formula ##STR48## or a pharmaceutically acceptable salt thereof, wherein Y is oxygen or ##STR49## R.sub.1 is hydrogen, alkyl having from one to five carbon atoms, arylalkyl wherein the aryl portion is phenyl or substituted phenyl, phenyl or substituted phenyl and R.sub.2 is hydrogen or alkyl and wherein the substituted phenyl groups are those substituted with one, two or three halogen, hydroxyl, alkyl, alkoxy, carbamoyl or carboxyl groups.
A complex, or a pharmaceutically acceptable salt of a complex, of a metal-chelating ligand having the formula ##STR56## wherein Y is oxygen or ##STR57## R.sub.1 is hydrogen, alkyl having from one to five carbon atoms, arylalkyl wherein the aryl portion is phenyl or substituted phenyl, phenyl or substituted phenyl wherein the substituted phenyl groups are those substituted with one, two or three halogen, hydroxyl, alkyl, alkoxy, carbamoyl or carboxyl groups and R.sub.2 is hydrogen or alkyl and a paramagnetic metal atom.
Dependencies are inferred from the claim text.