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US 4,880,839 AGranted
Acyanilide derivatives
AssigneeImperial Chemical Industries PLC
InventorHoward Tucker
Life of this patent
Estimating the term…
Abstract
An acylanilide of the formula: ##STR1## wherein R.sup.1 or R.sup.2 which may be the same or different, each is an electron-withdrawing substituent, alkylthio or phenylthio or R.sup.1 is hydrogen, alkyl or alkoxy; wherein R.sup.3 is hydrogen or halogen; wherein R.sup.4 is hydrogen or acyl wherein A is branched-chain alkylene; and wherein R.sup.5 is phenyl, substituted phenyl or naphthyl. The compounds possess progestational activity.
Claims6
An acylanilide of the formula:
- ##STR5## wherein R.sup.1 is carbamoyl, nitro, fluoro, chloro, bromo, iodo or hydrogen, or alkyl, alkoxy, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, perfluoroalkyl, perfluoroalkylthio, perfluoroalkylsulphinyl or perfluoroalkylsulphonyl each of up to 4 carbon atoms, or phenylthio, phenylsulphinyl or phenylsulphonyl;
- wherein R.sup.2 is carbamoyl, nitro, fluoro, chloro, bromo or iodo, or alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, perfluoroalkyl, perfluoroalkylthio, perfluoroalkylsulphinyl or perfluoroalkylsulphonyl each of up to 4 carbon atoms, or phenylthio, phenylsulphinyl or phenylsulphonyl;
- wherein R.sup.3 is hydrogen or halogen;
- wherein R.sup.4 is hydrogen;
- wherein A is branched-chain alkylene of up to 6 carbon atoms;
- and wherein R.sup.5 is phenyl which is unsubstituted or which bears one, two or three substituents selected from halogen, nitro, hydroxy, carboxy, carbamoyl and alkyl, alkoxy, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, perfluoroalkyl, perfluoroalkylthio, perfluoroalkylsulphinyl, perfluoroalkylsulphonyl, alkoxycarbonyl and N-alkylcarbamoyl each of up to 4 carbon atoms, and phenyl, phenylthio, phenylsulphinyl and phenylsulphonyl;
- or R.sup.5 is naphthyl.
4 more elements
The compound N-(2-hydroxy-4-phenyl-2-trifluoromethylpentanoyl)-4-nitro-3-trifluoromethy laniline in either of its diastereoisomeric forms.
Dependencies are inferred from the claim text.