Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
AssigneeBrigham Young University
InventorsRoland K. Robins, Howard B. Cottam
Life of this patent
Estimating the term…
Abstract
Compounds of the structure: ##STR1## wherein R.sub.1 and R.sub.2 individually are H or C.sub.1 -C.sub.18 acyl and R.sub.3 is H, C.sub.1 -C.sub.18 acyl or ##STR2## or R.sub.1 is H and together R.sub.2 and R.sub.3 are ##STR3## and X is .dbd.O or .dbd.S, Y is --OH, --SH, --NH.sub.2 or halogen, and Z is H, --NH.sub.2, --OH or halogen, wherein halogen is Cl or Br, or a pharmaceutically acceptable salt thereof are useful as antivirals, antitumors and as immune system enhancers.
Claims17
A method of treating viral diseases in mammals which consists of
- administering to said mammals a therapeutic effective amount of a compound of the structure:
- ##STR8## wherein R.sub.1 and R.sub.2 individually are H or C.sub.1 -C.sub.18 acyl and R.sub.3 is H, C.sub.1 -C.sub.18 acyl or ##STR9## or R.sub.1 is H and together R.sub.2 and R.sub.3 are ##STR10## and X is .dbd.O or .dbd.S, Y is --OH, --SH, and Z is H, --NH.sub.2, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition containing a therapeutically effective amount of 5-amino-3-.beta.-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(6H)-dione or a pharmaceutically acceptable salt thereof in combination with a therapeutically acceptable diluent or carrier.
A pharmaceutical composition containing a prophylactically effective amount of 5-amino-3-.beta.-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(6H)-dione or a pharmaceutically acceptable salt thereof in combination with an acceptable diluent or carrier.
A method of treating rhabdovirus, picornavirus, coronavirus, togavirus, bunyavirus, flavivirus, herpesvirus and cytomegalovirus in an afflicted host, said method consisting of:
- administering to said host a therapeutic effective amount of the compound 5-amino-3-.beta.-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(6H)-dione.
A method of treating rhabdovirus, picornavirus, coronavirus, togavirus, bunyavirus, flavivirus, herpesvirus and cytomegalovirus in an afflicted host, said method consisting of:
- administering to said host a therapeutic effective amount of a compound of the structure:
- ##STR13## wherein R.sub.1 and R.sub.2 individually are H or C.sub.1 -C.sub.18 acyl and R.sub.3 is H, C.sub.1 -C.sub.18 acyl or ##STR14## or R.sub.1 is H and together R.sub.2 and R.sub.3 are ##STR15## and X is .dbd.O or .dbd.S, Y is --OH, --SH, and Z is H, --NH.sub.2, or a pharmaceutically acceptable salt thereof.
A method of treating togavirus, bunyavirus, flavivirus, herpesvirus and cytomegalovirus in an afflicted host, said method consisting of:
- administering to said host a therapeutic effective amount of the compound 5-amino-3-.beta.-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(6H)-dione.
A method of treating togavirus, bunyavirus, flavivirus, herpesvirus and cytomegalovirus in an afflicted host, said method consisting of:
- administering to said host a therapeutic effective amount of a compound of the structure:
- ##STR18## wherein R.sub.1 and R.sub.2 individually are H or C.sub.1 -C.sub.18 acyl and R.sub.3 is H, C.sub.1 -C.sub.18 acyl or ##STR19## or R.sub.1 is H and together R.sub.2 and R.sub.3 are ##STR20## and X is .dbd.O or .dbd.S, Y is --OH, --SH, and Z is H, --NH.sub.2 or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.