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US 4,880,616 AGranted
Stable stannous chloride composition for labeling with radioactive technetium
AssigneeNihon Medi-Physics Co., Ltd.
InventorsMakoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
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Abstract
A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.
Claims2
A process for preparing a technetium 99m-labeled radioactive diagnostic agent consisting essentially of the steps of:
- (a) preparing a solution of stannous chloride in a concentration of not less than 1.0 mol/liter by dissolving stannous chloride alone in water,
- (b) charging solution prepared in step (a) to a container in an amount of not more than 500 microliters,
- (c) lyophilizing to provide stannous chloride in a dry solid state in said container,
- (d) adding water to said container to dissolve the stannous chloride therein and admixing .sup.99m Tc in the pertechnetate form to form .sup.99m Tc-labeled tin colloid.
1 more element
Dependencies are inferred from the claim text.