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US 4,880,610 AGranted
In situ calcium phosphate minerals--method and composition
AssigneeNorian Corporation
InventorBrent R. Constantz
Life of this patent
Estimating the term…
Abstract
Calcium phosphate minerals are formed by using highly concentrated phosphoric acid in conjunction with a calcium source, normaly as carbonate or a combination of carbonate and hydroxide, optimally in conjunction with calcium phosphate crystals and additional base to neutralize the phosphoric acid. Protein may be optionally added. The resulting product is readily formed and then sets to a hard, stable, workable shaped object.
Claims12
A method for making calcium phosphate minerals comprising:
- combining phosphoric acid substantially free of uncombined water, a calcium source, neutralizing anions including at least one of carbonate, phosphate and hydroxide in an amount sufficient to substantially neutralise said phosphoric acid and water in an amount to provide a kneadable mixture at a physiologically acceptable temperature;
- agitating the mixture to produce a substantially uniform mixture;
- and
- allowing the mixture to set and become annealed to a hard workable structure.
1 more element
A method for making hydroxyapatite comprising:
- combining orthophosphoric acid crystals, calcium carbonate, at least one of alkali metal or calcium hydroxide in an amount to provide a substantially neutral mixture, at a physiologically acceptable temperature, and water in an amount to provide a kneadable product;
- agitating the mixture to produce a substantially uniform mixture;
- and
- allowing the mixture to set and become annealed to a hard workable structure.
1 more element
Dependencies are inferred from the claim text.