Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
AssigneeArizona Board of Regents
InventorsGeorge R. Pettit, Yoshiaki Kamano
Life of this patent
Estimating the term…
Abstract
A new cytostatic depsipeptide, designated "dolastatin 15", was isolated from the Indian Ocean shell-like mollusk Dolabella auricularia. Dolastatin 15 inhibited growth of the PS leukemia with ED.sub.50 0.0024 .mu.g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 15, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 15 has the structural formula: ##STR1##
Claims8
A cell growth inhibitory substance denominated dolastatin 15 and having the structural formula:
- ##STR4##
A pharmaceutical preparation comprising a pharmaceutically acceptable carrier and an effective amount of a natural or synthetic substance or a non-toxic pharmaceutically active derivative thereof, said substance having the structural formula:
- ##STR5##
A method of treating a host afflicted with neoplastic disease comprising administering to said host an effective amount of a natural or synthetic substance or a pharmaceutically active non-toxic derivative thereof and a pharmaceutically acceptable carrier, said substance having the structural formula:
- ##STR6##
Dependencies are inferred from the claim text.