Treatment of infections with lymphokines
AssigneeCetus Corporation
InventorKong-Teck Chong
Life of this patent
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Abstract
Infections in mammalian hosts may be treated therapeutically or prophylactically with an effective amount of at least one lymphokine before or after host infection, the amount being sufficient to achieve at least 50% protection of the host. Preferably, the lymphokine is IL-2 or a combination of TNF and IL-2 or TNF and IFN-.gamma.. Also, preferably the infection is bacterial and is being treated prophylactically. The combination of TNF and IL-2 or TNF and IFN-.gamma. is administered in synergistically effective amounts.
Claims16
A method for prophylactic or therapeutic treatment of bacterial infections in mammalian hosts comprising administering an effective amount of tumor necrosis factor (TNF) from a mammalian species, to the host, before or after infection of the host, wherein the amount of TNF is a sufficient dose to achieve at least 50% protection of the host.
A method for prophylactic or therapeutic treatment of bacterial infections in mammalian hosts comprising administering an effective amount of tumor necrosis factor (TNF) and interleukin-2 (IL-2), both from a mammalian species, to the host, before or after infection of the host, wherein the amount of TNF and IL-2 is a sufficient dose to achieve at least 50% protection of the host.
A method for propylactic or therapeutic treatment of bacterial infections in mammalian hosts comprising administering an effective amount of tumor necrosis factor (TNF) and interferon-gamma (IFN-.gamma.), both from a mammalian species, to the host, before or after infection of the host, wherein the amount of TNF and IFN-.gamma. is a sufficient dose to achieve at least 50% protection of the host.
A method for prophylactic or therapeutic treatment of bacterial infections in human host comprising administering an effective amount of recombinant microbial produced human TNF to said host before or after the infection, wherein said amount of TNF is a sufficient dose to achieve at least 50% protection of said host.
A method for prophylactic or therapeutic treatment of gram negative bacterial infections in human host comprising administering an effective amount of recombinant microbial produced human TNF to said host before or after the infection, wherein said amount of TNF is a sufficient dose to achieve at least 50% protection of said host.
Dependencies are inferred from the claim text.