Vaccine containing tumor antigens and adjuvants
AssigneeRibi ImmunoChem Research, Inc.
InventorJohn L. Cantrell
Life of this patent
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Abstract
Vaccines are provided which are composed of (a) non-toxic and highly effective adjuvants obtained from microbial sources, together with (b) tumor antigens. A wide variety of antigens can be employed in the vaccines and include, antigens obtained from tumors or cultures of tumor cells, such as ovarian cancers, melanomas, colorectal cancers, pancreatic cancers, renal cancers and the like. By adding tumor antigens to potent but non-toxic immunostimulants, a protective and lasting tumor immunity can be obtained.
Claims22
A vaccine useful for the treatment and prevention of tumors in a host, said vaccine comprised of:
- (a) at least one tumor-associated antigen,
- (b) a refined detoxified endotoxin immunostimulant, and
- (c) at least one biological immunostimulant selected from the group consisting of:
- (1) mycobacterial cell wall skeleton
- (2) trehalose dimycolate, and
- (3) pyridine soluble extract of a microorganism, and
- (d) a pharmaceutically acceptable carrier.
A process for the preparation fo a vaccine useful for the treatment and prevention of tumors in a host which comprises forming a mixture of:
- (a) at least one tumor associated antigen
- (b) a refined detoxified endotoxin
- (c) at least one biological immunostimulant selected from the group consisting of:
- (1) mycobacterial cell wall skeleton
- (2) trehalose dimycolate, and
- (3) pyridine soluble extract of a microorganism, and
- (d) a pharmaceutically acceptable carrier
A process for the treatment and prevention of tumors in a host, which comprises administering to said host an anti-tumor effective amount of a vaccine comprised of:
- (a) at least one tumor associated antigen,
- (b) a refined detoxified endotoxin immunostimulant, and
- (c) at least one biological immunostimulant from the group consisting of:
- (1) mycobacterial cell wall skeleton,
- (2) trehalose dimycolate, and
- (3) pyridine soluble extract of a microorganism, and
- (d) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.