US 4,876,260 A · Oxathiolanes

Abstract

The present invention accordingly provides in one aspect, novel spiro-oxathiolane/quinuclidine compounds corresponding with the schematic structural formula (I) ##STR1## and geometrical isomers, enantiomers, diastereoisomers, racemates and acid addition salts thereof, wherein one of Y and Z is 0 and the other is S(.dbd.O).sub.n ; n is 0, 1 or 2; R' and R" are each selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, aminoalkyl, C.sub.3-7 cycloalkyl, aryl, diarylmethylol, and alkyl substituted by at least one aryl group, provided that at least R' and R" is other than hydrogen; and each X is hydrogen, or when Y is 0 and Z is S(.dbd.O).sub.n simultaneously, then each X may also be selected from the group consisting of deuterium and tritium, and provided further that when each X is hydrogen, Y is 0 and Z is S simultaneously, then at least one of R' and R" is selected from the group consisting of alkenyl, alkynyl, cyclopropyl, cyclobutyl, cycloheptyl, hydroxyalkyl and aminoalkyl.

Claims43

Dependent claims

A compound of the formula (I) ##STR4## and geometrical isomers, enantiomers, diastereoisomers, racemates and acid addition salts thereof, wherein one of Y and Z is O and the other is S(.dbd.O).sub.n ;

n is 0, 1 or 2;
R' and R" are each selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, hydroxy lower alkyl, amino lower alkyl, C.sub.3-7 cycloalkyl, phenyl, diphenyl methylol, and lower alkyl substituted by one or two phenyl groups, provided that at least R' or R" is other than hydrogen;
and each X is hydrogen, or when Y is O and Z is S(.dbd.O).sub.n simultaneously, then each X may also be selected from the group consisting of deuterium and tritium, and provided further that when each X is hydrogen, Y is O and Z is S simultaneously, then at least one of R' and R" is selected from the group consisting of lower alkenyl, lower alkynyl, cyclopropyl, cyclobutyl, cycloheptyl, hydroxy lower alkyl and amino lower alkyl.

Dependencies are inferred from the claim text.

Oxathiolanes

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Oxathiolanes

Life of this patent

Abstract

Claims43