Back to results
US 4,876,243 AGranted
Vasopressin compounds
AssigneeSmithKline Beckman Corporation
InventorsGarland R. Marshall, Michael L. Moore
Life of this patent
Estimating the term…
Abstract
Vasopressin-like peptide whose structures have been modified by an alpha-methyl amino acid at the 4 or 7 position are set forth. These compounds have potent vasopressin antagonist activities.
Claims14
A chemical compound having the formula:
- ##STR4## in which:
- Z is a D or L-isomer of Cys;
- X is Val, Chg, Gln, Cha, Phe, Lys or .alpha.-MeAA;
- Y is a D or L-isomer of Pro, Arg, HArg or MeArg, a single bond or .alpha.-MeAA, .alpha.-MePro, .alpha.-MeLys or .alpha.-MeArg;
- at least one of X and Y being a said .alpha.-Me amino acid group;
- A is a D or L-isomer of Tyr, Tyr(Alk), Phe or 4'-AlkPhe;
- B is a D or L-isomer of Arg MeArg or HArg or, when C is Cad, a single bond;
- C is Gly, Gly(NH.sub.2), Cad, OH or NH.sub.2 ;
- and
- n is 0 or 1, or a pharmaceutically acceptable salt or ester prodrug thereof.
7 more elements
Dependencies are inferred from the claim text.