Organic fluoride sources
AssigneeMinnesota Mining and Manufacturing Company
InventorsSteven M. Aasen, Joel D. Oxman, F. Andrew Ubel, III
Life of this patent
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Abstract
Organic fluoride sources comprising a tetrafluoroborate salt and capable of releasing fluoride ions into dentition in order to provide inhibition and/or prevention of dental caries are disclosed. A method of releasing fluoride ion into dental tissue is also disclosed.
Claims22
A polymerizable composition which releases fluoride to dental tissue and which comprises one or more polymerizable monomers and, as a fluoride source, an organic compound comprising one or more tetrafluoroborate salt moieties, the cations of which are selected from the group consisting of quaternary ammonium, iodonium, sulfonium and phosphonium, the fluoride source being capable of providing fluoride to the surrounding tissue, and being present in the polymerizable composition in an amount sufficient to inhibit the progression of and/or prevent dental caries, and being substantially soluble in and/or polymerizable with the polymerizable monomer.
A polymerizable composition according to claim2, wherein the fluoride source is of the formula ##STR7## wherein M is I, N, P or S;
- n is 2 when M is I, n is 3 when M is S, and n is 4 when M is N or P;
- and each R group is independently selected from the group consisting of straight chain or branched chain alkyl of 1 to about 12 carbon atoms;
- substituted straight chain or branched chain alkyl of 1 to about 12 carbon atoms;
- phenyl;
- and substituted phenyl, with the proviso that when R is substituted alkyl or substituted phenyl, there are 1 or 2 substituents selected independently from the group consisting of straight chain or branched chain alkyl or alkoxy of 1 to about 8 carbon atoms, halogen, phenyl, amino, mono- or dialkyl amino wherein the alkyl group(s) is straight chain or branched chain of 1 to about 8 carbon atoms, mercapto and a moiety of the formula ##STR8## wherein M and n are as defined above and each R.sup.I group is independently selected from the group consisting of straight chain or branched chain alkyl of 1 to about 8 carbon atoms;
- substituted straight chain or branched chain alkyl of 1 to about 8 carbon atoms;
- phenyl;
- and substituted phenyl, with the proviso that when R.sup.I is substituted alkyl or substituted phenyl, there are 1 or 2 substituents selected independently from the group consisting of straight chain or branched chain alkyl or alkoxy of 1 to about 8 carbon atoms, halogen, amino, mono- or dialkyl amino wherein the alkyl group(s) is straight chain or branched chain alkyl of 1 to about 8 carbon atoms, and mercapto.
Dependencies are inferred from the claim text.