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US 4,870,186 AGranted
Tetrazole intermediates to antihypertensive compounds
AssigneeE. I. Du Pont de Nemours and Company
InventorsPaul E. Aldrich, John J. V. Duncia, Michael E. Pierce
Life of this patent
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Abstract
Tetrazole intermediates useful to prepare antihypertensive compounds described in coassigned application U.S. Ser. No. 884,920, filed July 11, 1986, are described, these tetrazoles have the formula: ##STR1## wherein X.sup.1 and X.sup.2 are as described in the specification.
Claims5
A tetrazole having the formula:
- ##STR22## wherein X.sup.1 is H, --C(Phenyl).sub.3, p-nitrobenzyl, or .beta.-propionitrile,
- X.sup.2 is ##STR23## R.sup.1 is alkyl of 3-10 carbon atoms, alkenyl of 3 to 10 carbon atoms, alkenyl of 3 to 10 carbon atoms, alkynyl of 3 to 10 carbon atoms, and benzyl substituted with up to two groups selected from alkoxy of 1 to 4 carbon atoms, halogen, alkyl of 1 to 4 carbon atoms, nitro and amino;
- R.sup.2 is ##STR24## R.sup.3 is H, F, Cl, Br, I, NO.sub.2, CF.sub.3, or CN;
- R.sup.6 is NR.sup.10 R.sup.11 ;
- R.sup.10 and R.sup.11 taken together to form a ring of the Formula ##STR25## Q is NR.sup.12, O or CH.sub.2 ;
- R.sup.12 is H, alkyl of 1 to 4 carbon atoms, or phenyl;
- n is 1 to 10;
- s is 0 to 5;
- t is 0;
- with the proviso that when X.sup.1 =H then X.sup.2 cannot be ##STR26##
7 more elements
Dependencies are inferred from the claim text.