Segmented polypeptide bioelastomers to modulate elastic modulus
AssigneeUniversity of Alabama at Birmingham
InventorsDan W. Urry, U. Prasad Kari
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Abstract
A method of increasing the modulus of elasticity of a biopolymer is disclosed, which comprises incorporating a hexameric unit of the formula --X--(APGVGV).sub.n --Y-- wherein A is a peptide-forming residue of L-alanine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; X is PGVGV, GVGV, VGV, GV, V, or a covalent bond; Y is APGVG, APGV, APG, AP, A, or a covalent bond; and n is an integer from 2 to 200, wherein said hexameric unit comprises at least 18 amino acid residues, into an elastomeric polypeptide chain.
Claims14
A method of increasing the modulus of elasticity of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide and pentapeptide repeating units and mixtures thereof wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues and wherein said repeating units exist in a conformation having a .beta.-turn, which comprises:
- chemically bonding a hexapeptide unit of the formula
- --X--(APGVGV).sub.n --Y--
- wherein
- A is a peptide-forming residue of L-alanine;
- P is a peptide-forming residue of L-proline;
- G is a peptide-forming residue of glycine;
- V is a peptide-forming residue of L-valine;
- X is PGVGV, GVGV, VGV, GV, V, or a covalent bond;
- Y is APGVG, APGV, APG, AP, A, or a covalent bond;
- and
- n is an integer from 2 to 200, wherein said hexameric unit comprises at least 18 amino acid residues, into a polypeptide chain of said bioelastomer in an amount sufficient to increase the modulus of elasticity of said bioelastomer.
A bioelastomer containing repeating units selected from the group consisting of elastomeric and pentapeptide repeating units and mixtures thereof wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues and wherein said repeating units exist in a conformation having a .beta.-turn, which is produced by:
- chemically bonding a hexapeptide unit of the formula
- --X--(APGVGV).sub.n --Y--
- wherein
- A is a peptide-forming residue of L-alanine;
- P is a peptide-forming residue of L-proline;
- G is a peptide-forming residue of glycine;
- V is a peptide-forming residue of L-valine;
- X is PGVGV, GVGV, VGV, GV, V, or a covalent bond;
- Y is APGVG, APGV, APG, AP, A, or a covalent bond;
- and
- n is an integer from 2 to 200, wherein said hexameric unit comprises at least 18 amino acid residues, into a polypeptide chain of said bioelastomer in an amount sufficient to increase the modulus of elasticity of said bioelastomer.
Dependencies are inferred from the claim text.