Method of stimulating integumental melanocytes by topical application of analogs of alpha-msh
AssigneeUniversity Patents, Inc.
InventorsVictor J. Hruby, Mac E. Hadley, Robert Dorr, Norman Levine, Elizabeth Sugg, Wayne L. Cody
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Abstract
A method for stimulating integumental melanocytes by the topical application of alpha-MSH analogs, and compositions comprising said analogs for use in the method are described.
Claims21
A method of stimulating melanin production in a vertebrate which comprises administering to said vertebrate in an amount sufficient to cause stimulation of melanocytes a compound of the group:
- (1) alpha-MSH having the amino acid formula:
- Ac--Ser--Tyr--Ser--Met--Glu--His--Phe--Arg--Trp--Gly--Lys--Pro--Val--NH.sub .2 ;
- (2) Alpha-MSH analogues having the formula:
- Ac--Ser--Tyr--Ser--M--Glu--His--D--Phe--Arg--Trp--Gly--Lys--ProVal--NH.sub. 2 wherein M is selected from the group consisting of Met, Nle, and Cys;
- (3) analogues of alpha-MSH having the formula:
- R.sub.1 --W--X--Y--Z--R.sub.2
- wherein R.sub.1 is selected from the group consisting of
- Ac--Gly, Ac--Met--Glu, Ac--Nle--Glu and Ac--Tyr--Glu;
- wherein W is selected from the group consisting of His, and D--His;
- wherein X is selected from the group consisting of Phe, D--Phe, Tyr, D--Tyr, and (pNO.sub.2)D--Phe;
- wherein Y is selected from the group consisting of Arg and D--Arg;
- wherein Z is selected from the group consisting of Trp and D--Trp;
- and
- wherein R.sub.2 is selected from the group consisting of NH.sub.2, Gly--NH.sub.2, and Gly--Lys--NH.sub.2 ;
- and
- (4) alpha-MSH analogues selected from the group consisting of
- [Nle.sup.4, D--Phe.sup.7 ]--alpha--MSH
- [Nle.sup.4, D--Phe.sup.7 ]--alpha--MSH.sub.4-10
- [Nle.sup.4, D--Phe.sup.7 ]--alpha MSH.sub.4-11
- [Nle.sup.4, D--Phe.sup.7, D--Trp.sup.9 ]--alpha--MSH.sub.4-11
- [Nle.sup.4, D--Phe.sup.7 ]--alpha--MSH.sub.4-9
A method for the stimulation of integumental melanocytes in a vertebrate which comprises administrating topically to the epidermal tissue of said vertebrate in an amount sufficient to cause stimulation, a compound of the group:
- (1) alpha-MSH having the amino acid formula:
- Ac--Ser--Tyr--Ser--Met--Glu--His--Phe--Arg--Trp--Gly--Lys--Pro--Val--NH.su b.2 ;
- (2) alpha--MSH analogues having the formula:
- Ac--Ser--Tyr--Ser--M--Glu--His--D--Phe--Arg--Trp--Gly--Lys--Pro--Val--NH.s ub.2 wherein M is selected from the group consisting of Met, Nle and Cys;
- (3) analogues of alpha--MSH having the formula:
- R.sub.1 --W--X--Y--Z--R.sub.2 wherein R.sub.1 is selected from the group consisting of Ac--Gly, Ac--Met--Glu,Ac--Nle--Glu, and Ac--Tyr--Glu' wherein W is selected from the group consisting of His and D--His;
- wherein X is selected from the group consisting of Phe, D--Phe--Tyr, D--Tyr, and (pNO.sub.2)D--Phe;
- wherein Y is selected from the group consisting of Arg and D--Arg;
- wherein Z is selected from the group consisting of Trp and D--Trp;
- and wherein R.sub.2 is selected from the group consisting of NH.sub.2, Gly--N.sub.2 and Gly--Lys--NH.sub.2 ;
- and (4) alpha--MSH analogues selected from the group consisting of
- [Nle.sup.4, D--Phe.sup.7 ]--alpha--MSH
- [Nle.sup.4, D--Phe.sup.7 ]--alpha--MSH.sub.4-10
- [Nle.sup.4, D--Phe.sup.7 ]--alpha--MSH.sub.4-11
- [Nle.sup.4, D--Phe.sup.7, D--Trp.sup.9 [--alpha--MSH.sub.4-11
- [Nle.sup.4, D--Phe.sup.7 ]--alpha--MSH.sub.4-9
Dependencies are inferred from the claim text.