Back to results
US 4,863,932 AGranted
Squalene oxide cyclase inhibitors and therapeutic use thereof
AssigneesSomatogenetics International, Inc., Dartmouth College
InventorsMichael Sinensky, Thomas A. Spencer
Life of this patent
Estimating the term…
Abstract
Azadecalins and C-7 substituted decalins with squalene oxide cyclase inhibitory activity are useful as inhibitors of cholesterol synthesis and hence may be used in pharmaceuticals for regulating cholesterol levels in a mammal.
Claims12
A compound having one of the structure shown in formulas (I) and (II) below:
- ##STR3## wherein R.sub.1 is methyl, ethyl, or forms a cyclopropane ring with R.sub.2 ;
- R.sub.2 is methyl, ethyl, or forms a cyclopropane ring with R.sub.1, but R.sub.1 and R.sub.2 are not both ethyl;
- R.sub.3 is hydrogen, an alkyl of no more than five carbon atoms, fluorine, chlorine or bromine;
- R.sub.4 is hydrogen, an hydroxy alkyl of no more than 5 carbon atoms, fluorine, chlorine or bromine, where R.sub.3 and R.sub.4 may be the same or different, and where R.sub.3 and R.sub.4 may form a cyclopropane ring;
- R.sub.5 is hydrogen, methyl, ethyl, propyl, isopropyl, or CH.sub.2 OH;
- R.sub.6 is hydrogen, methyl or ethyl;
- and
- R.sub.7 is hydrogen, methyl or ethyl;
- and wherein if the compound is of formula (I), then one or more of R.sub.3, R.sub.4 or R.sub.5 is not hydrogen.
6 more elements
Dependencies are inferred from the claim text.