Method for isomerization of trans-form 2-methylspiro (1,3-oxathiolane-5,3') q
AssigneeIshahara Sangyo Kaisha Ltd
InventorsTakahiro Haga, Itaru Shigehara, Toru Koyanagi, Kazutoshi Hara, Masaru Maeda
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Abstract
A method for isomerization of trans-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof, which comprises isomerizing said trans-form quinuclidine or acid addition salts thereof to cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof in the presence of at least one acid catalyst selected from the group consisting of an organic sulfuric acid, a halide functioning as a Lewis acid, and sulfuric acid.
Claims10
A method for isomerization of trans-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof which comprises isomerizing said trans-form quinuclidine or acid addition salts thereof to cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof in the presence of at least one acid catalyst selected from the group consisting of an organic sulfonic acid, a halide functioning as a Lewis acid, and sulfonic acid.
Dependencies are inferred from the claim text.