Wound healing and bone regeneration using PDGF and IGF-I
AssigneesInstitute of Molecular Biology, Inc., President and Fellows of Harvard College
InventorsHarry N. Antoniades, Samuel E. Lynch, Ray C. Williams
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Abstract
Healing an external wound or regenerating bone of a mammal by administering to the mammal a composition containing purified platelet-derived growth factor and purified insulin-like growth factor.
Claims9
A method for healing an external wound of a mammal comprising applying to said wound a wound-healing amount of a composition comprising platelet-derived growth factor and insulin-like growth factor-1, each said platelet-derived growth factor and insulin-like growth factor-1 being pure so as to yield a single major band on a polyacrylamide gel.
A method for regenerating bone of a mammal comprising administering to said mammal a wound-healing amount of a composition comprising platelet-derived growth factor and insulin-like growth factor-1, each said platelet-derived growth and insulin-like growth factor-1 being pure so as to yield a single major band on a polyacrylamide gel.
A wound healing and bone regenerating composition comprising platelet-derived growth factor and insulin-like growth factor-1, in a weight to weight ratio of 1:4 to 25:1, each said platelet-derived growth factor and insulin-like growth factor-1 being pure so as to yield a single major band on a polyacrylamide gel, in combination with a pharmaceutically acceptable carrier substance.
A method for preparing a composition for healing wounds, comprising mixing platelet-derived growth factor and insulin-like growth factor-1 in a weight to weight ratio of between 1:4 and 25:1, in combination with a pharmaceutically acceptable carrier substance, each said platelet-derived growth factor and insulin-like growth factor-1 being pure so as to yield a single major band on a polyacrylamide gel.
Dependencies are inferred from the claim text.