Cellular encapsulation of biologicals for animal and human use
AssigneeMycogen Corporation
InventorsAndrew C. Barnes, David L. Edwards
Life of this patent
Estimating the term…
Abstract
A biological delivery system particularly suited for delivery of protein compounds to animals and humans is disclosed. The system uses a producing microbe itself after suitable treatment by chemical and/or physical means. The product being delivered is contained within the treated microbial cell; it is produced intracellularly by a homologous (native) gene.
Claims44
A microbial delivery means for use in animals or humans consisting essentially of a microbe comprising a desired intracellular compound produced by a homologous gene, said microbe, while substantially intact, treated with chemical or physical means sufficient to render said microbe non-proliferative, and stabilize the microbial cell without significant loss of activity of the intracellular compound.
A process for delivering a compound to an animal or human body which comprises administering to said animal or human body a microbe comprising a desired intracellular compound produced by a homologous gene, said microbe, while substantially intact, treated with chemical or physical means sufficient to render said microbe non-proliferative, and stabilize the microbial cell without significant loss of activity of the intracellular compound.
A process for treating an animal or human hosting a nematocide infestation which comprises administering to said animal or human a nematocide compound effective to control said infestation, wherein said nematocide compound is delivered to said animal or human host by a microbial delivery means consisting essentially of a microbe comprising a desired intracellular compound produced by a homologous gene, said microbe, while substantially intact, treated with chemical or physical means sufficient to render said microbe nonproliferative, and stabilize the microbial cell without significant loss of activity of the intracellular compound.
A feed supplement comprising a microbe comprising a desired intracellular compound produced by a homologous gene, said microbe, while substantially intact, treated with chemical or physical means sufficient to render said microbe non-proliferative, and stabilize the microbial cell without significant loss of activity of the intracellular compound.
Dependencies are inferred from the claim text.