Terpyridine chelating agents
AssigneeEastman Kodak Company
InventorJohn L. Toner
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Abstract
There are described stable fluorescent labels comprising a complex of Eu.sup.+3 and a chelating agent comprising a nucleus which is a triplet sensitizer having a triplet energy greater than that of Eu.sup.+3 and at least two heteroatom-containing groups which form coordinate complexes with Eu.sup.+3 and a third heteroatom-containing group or heteroatom in or appended to the triplet sensitizer. Labeled physiologically active materials useful in specific binding assays such as labeled antigens, haptens, antibodies, hormones and the like comprising the stable fluorescent labels having physiologically active materials adsorbed or bonded thereto are also described.
Claims1
A compound selected from those having the following structures ##STR29## wherein R.sup.4 represents --H, --SCH.sub.3, --OCH.sub.3, --CN, --NO.sub.2, --CO.sub.2 CH.sub.3, --CH.sub.3 ;
- ##STR30## wherein R.sup.5 represents --CH.sub.3, --NO.sub.2, --OCH.sub.3 ;
- ##STR31## wherein R.sup.5 represents --CH.sub.3, --NO.sub.2, or --OCH.sub.3. ##STR32## wherein R.sup.9 represents --H, --OCH.sub.3, --NO.sub.2 ;
- ##STR33## wherein R.sup.7 represents --H, --OCH.sub.3, --NO.sub.2 ;
- and ##STR34## wherein R.sup.8 represents H, --OCH.sub.3, --NO.sub.2.
Dependencies are inferred from the claim text.