Antiviral agents
AssigneeSymbicom AB
InventorsKarl-Anders Karlsson, Erling Norrby, Goran Wadell
Life of this patent
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Abstract
A second-step virus binding receptor is found in nature on the surface of animal and plant cells. This receptor is thought to be needed for virus penetration into target cells. The second-step receptor has been found to bind a wide variety of viruses belonging to a number of different families. The second-step receptor and natural or synthetic substances which correspond to or are analogous to the binding epitope of the second-step receptor in that they are able to bind to a site on the virus which recognizes the binding epitope of the natural second-step receptor, are therefore indicated for the diagnosis, prophylaxis or treatment of viral infections.
Claims13
A method of inhibiting the interaction between a cellular second-step viral binding receptor and a virus which comprises exposing the virus to a compound having the formula:
- ##STR29## where R is a carbohydrate moity, R.sub.1 and R.sub.3 are selected independently from the group consisting of methyl, a reactive group, and a macromolecular carrier, and R.sub.2 and R.sub.4 are hydrocarbons with a chain length of at least five carbon atoms, and may be the same or different, and where said compound preferentially binds the viral recognition site for the binding epitope of a cellular second-step viral binding receptor, whereby the binding of the virus to the receptor is inhibited.
A method of inhibiting the interaction between a cellular second-step viral binding receptor and a virus which comprises exposing the virus to a compound having the formula:
- ##STR30## where R is a carbohydrate moiety, R.sub.1 and R.sub.3 are selected independently from the group consisting of methyl, a reactive group, and a macromolecular carrier, and R.sub.2 and R.sub.4 are hydrocarbons with a chain length of at least five carbon atoms, and may be the same or different, and where said compound preferentially binds the viral recognition site for the binding epitope of a cellular second-step viral binding receptor, whereby the binding of the virus to the receptor is inhibited.
A method of inhibiting the interaction between a cellular second-step viral binding receptor and a virus which comprises exposing the virus to a compound have the formula:
- ROCH.sub.2 --SO.sub.2 --R.sub.2 --R.sub.1
- where R is a carbohydrate moiety, R.sub.1 is selected independently from the group consisting of methyl, a reactive group, and a macromolecular carrier, and R.sub.2 is a hydrocarbon with a chain length of at least five carbon atoms, and where said compound preferentially binds the viral recognition site for the binding epitope of a cellular second-step viral binding receptor, whereby the binding of the virus to the receptor is inhibited.
A method of inhibiting the interaction between a cellular second-step viral binding receptor and a virus which comprises exposing the virus to a compound having the formula:
- ##STR31## where R is a carbohydrate moiety, R.sub.1 and R.sub.3 are selected independently from the group consisting of methyl, a reactive group, and a macromolecular carrier, R.sub.2 and R.sub.4 are hydrocarbons with a chain length of at least five carbon atoms, and may be the same or different, and R.sub.5 is selected from the group consisting of --CH.dbd.CH--, --CHOH--CH.sub.2 --, and --CH.sub.2 --CH.sub.2 --, and where said compound preferentially binds the viral recognition site for the binding epitope of a cellular second-step viral binding receptor, whereby the binding of the virus to the receptor is inhibited.
A method of inhibiting the interaction between a cellular second-step viral binding receptor and a virus which comprises exposing the virus to a compound which is D-galactopyranosyl-beta-diglyceride or a higher saccharide derivative thereof.
Dependencies are inferred from the claim text.