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AssigneeMerck & Co., Inc.
InventorsYiu-kuen T. Lam, Raymond S. Chang, Otto D. Hensens, Cheryl D. Schwartz, Deborah L. Zink
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Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis.
A method of treating cholecystokinin and gastrin induced gastrointestinal disorders in mammals which comprises administering a pharmaceutically effective amount of virginiamycin M.sub.1.
A method of treating cholecystokinin and gastrin induced gastrointestinal disorders in mammals which comprises administering a pharmceutically effective amount of the compound of Formula I:
A method of treating cholecystokinin and gastrin induced gastrointestinal disorders in mammals which comprises administering a pharmaceutically effective amount of the compound of Formula II:
A method of treating cholecystokinin and gastrin induced gastrointestinal disorders in mammals which comprises administering a pharmaceutically effective amount of the compound of Formula III:
A method of treating cholecystokinin and gastrin induced gastrointestinal disorders in mammals which comprises administering a pharmecuatically effective amount of the compound of Formula IV:
A method of treating cholecystokinin and gastrin induced gastrointestinal disorders in mammals which comprises administering a pharmceutically effective amount of one or more of virginiamycin M.sub.1 and the compounds of:
A method of treating cholecystokinin and gastrin induced gastrointestianl disorders in mammals which comprises administering a pharmaceutically effective amount of one or more of virginiamycin M.sub.1 and the compounds of:
Dependencies are inferred from the claim text.