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US 4,857,311 AGranted
Polyanhydrides with improved hydrolytic degradation properties
AssigneeMassachusetts Institute of Technology
InventorsAbraham J. Domb, Robert S. Langer
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AssigneeMassachusetts Institute of Technology
InventorsAbraham J. Domb, Robert S. Langer
Estimating the term…
Polyanhydrides with uniform distribution of alkyl and aromatic residues are prepared by melt polycondensation or solution polymerization of p-carboxyphenoxyalkanoic acids or p-carboxyphenylalkanoic acids. These polymers are soluble in common organic solvents and have low melting points, generally in the range of 40.degree.-100.degree. C. The polyanhydrides are especially well suited for forming bioerodible matrices in controlled bioactive compound delivery devices. A polymeric matrix formed according to the method described here degrades uniformly during drug release, preventing the wholescale channeling of the bioactive compound into the environment, and eliminating the problem of the presence of the polymer matrix at the site long after drug release. The polymer displays zero-order kinetic degradation profiles over various periods of time (days to months), at a rate useful for controlled drug delivery. Furthermore, a desired degradation rate may be obtained by choosing the appropriate length of the aliphatic moiety.
A polyanhydride having the general formula ##STR4## wherein X is selected from the group consisting of O and CH.sub.2, n is an integer between 2 and 25, and y is at least 2, and
A method of preparing a controlled bioactive compound delivery device comprising
The method of claim 15 further comprising
A polyanhydride with the general formula ##STR7## wherein X is selected from the group consisting of O and CH.sub.2, Y is an aromatic, Z is an aliphatic having between 2 and 25 carbon molecules in the backbone, and y is at least 2, and
Dependencies are inferred from the claim text.