Back to results
US 4,851,426 AGranted
Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids and pharmaceutical compositions thereof
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsDavid Ladkani, Haim Yellin, Ben Z. Weiner, David Avnir
Life of this patent
Estimating the term…
Abstract
Novel esters of the general formula ##STR1## in which ##STR2## is the acyl residue of a non-steroidal anti-inflammatory compound containing a carboxylic acid function. The novel esters are prepared by reacting an acide R--COOH when R is as above, with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions containing any of the said novel esters.
Claims13
Ester of the formula:
- ##STR35## in which ##STR36## is the acyl residue of a non-steroidal anti-inflammatory compound containing a carboxylic acid function and at least one aromatic ring and being selected from the group consisting of
- 1-(p-chlorobenzyl)-5-methoxy-2-methylindole-3-acetic acid,
- (+)-6-methoxyl-.alpha.-methyl-2-naphthaleneacetic acid,
- .alpha.-methyl-4-(2-methylpropoyl)benzene-acetic acid,
- 2-((2,6-dichlorophenyl)amino)benzene-acetic acid,
- m-benzoylhydratropic acid,
- 2-((2,3-dimethylphenyl)amino)-benzoic acid,
- (Z)-5-fluoro-2-methyl-1-((4-methylsulfinyl)methylene)-1H-indene-3-acetic acid,
- 2-((3-(trifluoromethyl)phenyl)-amino)benzoic acid and
- 1-methyl-5-(.alpha.-methylbenzoyl)-1H-pyrrole-2-acetic acid.
7 more elements
Dependencies are inferred from the claim text.