Substrates coated with organo-silanes that are sterically-protected
AssigneeE. I. Du Pont de Nemours and Company
InventorsJoseph L. Glajch, Joseph J. Kirkland
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Abstract
This invention involves unique compositions consisting of substrates coated with organo-silanes that are sterically protected by a single bulky group. This material consists of an appropriate reactive solid to which is attached a silane whose silicon stom is bonded to a functional group that contains a dimethyl-substituted tertiary carbon.
Claims17
A stable support structure comprising a substrate and a monofunctional silane containing a single sterically-protecting, dimethyl-substituted, tertiary carbon moiety attached to the silicon atom of the silane and additional functional groups, R, R.sub.1, and R.sub.2, covalently attached to the substrate, the silane being as follows:
- ##STR4## where R, R.sub.1 and R.sub.2 are alkane, substituted alkane, alkene, substituted alkene, aryl or substituted aryl, but specifically excluded are structures where R=R.sub.1 =R.sub.2 =CH.sub.3 ;
- and A=a surface group of the substrate to which the silane is attached.
A stable support structure for peptide synthesis comprising a silica substrate, and a silane, arrange as follows:
- ##STR5## covalently attached to the silica substrate.
Dependencies are inferred from the claim text.