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US 4,845,084 AGranted
Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
AssigneeMerck & Co., Inc.
InventorsJohn Hannah, Richard L. Tolman
Life of this patent
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Abstract
Phosphate derivatives of substituted butyl guanines which have antiviral activity against DNA viruses, such as herpes viruses and HTLV-III.
Claims7
A compound of the formula:
- ##STR27## wherein R.sup.1 is hydroxy, amino or halogen;
- and R.sup.2 and R.sup.3 are independently selected from hydrogen and a phosphate group having the formula:
- ##STR28## provided that R.sup.2 and R.sup.3 are not concurrently hydrogen, or R.sup.2 and R.sup.3 taken together form a phosphate group having the formula:
- ##STR29## wherein R.sup.4 and R.sup.5 are independently selected from hydrogen, a pharmaceutically-acceptable cation, alkyl having 1 to 6 carbon atoms, phenyl or phenylalkyl wherein the alkyl moiety has 1 to 6 carbon atoms.
1 more element
Dependencies are inferred from the claim text.